Several benefits are associated to whole slide imaging of microscopy slides, such as the possibility to view and assess a complete specimen or sample at the required magnification, the chance to easily share the digital scans with colleagues or remote experts or the option to create high-quality images for publication.

With regards to fluorescent slides, their digitization comes with an additional specific advantage: by digitizing the slides, the quality of the stain is preserved. The issue of bleaching of the original glass slides over time can thus be circumvented.